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Choosing the Right Product 
A variety of 
quality 
of life issues can also be improved through physical activity.  These include 
range of motion, pain reduction, and emotional well-being. 
  
  
	
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		This 
		diagram illustrates one of the ways physical activity helps 
		to lower blood glucose levels.  Increasing the number and activity of 
		insulin receptors (marked in red) on the surface of muscle cells 
		accelerates the uptake of glucose.  A special enzyme called “glut 4,” 
		(the orange opening) produced during exercise, enhances glucose uptake 
		in a non-insulin-dependent manner.  These physiologic changes help the 
		body to become much more efficient at metabolizing glucose for energy. 
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Who is At Risk for Hypoglycemia? 
	
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Fear of 
hypoglycemia is 
one of the major obstacles to exercise for people with diabetes and their 
healthcare providers.  However, it is important to remember that hypoglycemia 
will not occur unless a patient is taking insulin or oral hypoglycemic agents – 
sulfonylureas or meglitinides.  No other diabetes medications or treatments 
produce hypoglycemia.  | 
	 
 
  
  
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Those who use premixed insulin (a combination of NPH and regular or rapid 
insulin) are at the greatest risk for hypoglycemia during exercise due to the 
untimely and inconsistent peak of the daytime NPH insulin.  Those taking oral 
medications that stimulate the production of extra insulin by the pancreas are 
at a small but ever-present risk of hypoglycemia.   
  
Attention must be given to making intelligent adjustments to minimize 
hypoglycemia risk in these individuals.  
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