After-Meal Highs: Immediate
Problems
For example, research in Australia showed how
post-meal glucose excursions affect childrens’
day to day performance. In this study, several
hundred parents were interviewed to identify
aspects of their children’s lives that changed
when glucose exceeded 15 mmol/l, or 270 mg/dl.
Parents reported a deleterious effect on
physical, cognitive and emotional performance at
these states of hyperglycemia.
Australian Study* of
Children with Type 1 diabetes. Parents &
children reported BG > 270 had negative
impact on:
Coordination (53%)
J Pediatr Endocrinol
Metab. 2006 Jul;19(7); 927-36
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Similar research on adults in the the US and UK
found a correlation between post-meal
hyperglycemia and several performance-related
outcomes, including the ability to think
clearly, state of worry, ability to interact on
a social level, energy levels, and performance
at work.
1200 T1 & T2 insulin
users in the US & UK surveyed.
Frequency and
severity of post-meal hyperglycemic
events
negatively
affects:
Thinking and
Concentration
Work Activities
Heller et al.
Towards a better understanding
of postprandial hyperglycemic
episodes in people with
diabetes: impact on daily
functioning. Current Medical
Research and Opinion. ISSN:
0300-7995; 1473-4877. 2018.
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Long-Term Problems
From a long-term standpoint, it has been shown that
postprandial glucose levels influence A1c –
particularly A1c levels below 7.5. Focusing solely
on fasting and premeal glucose levels may limit a
person’s ability to achieve A1c levels recommended
by the American Diabetes Association. In fact,
achieving an A1c of 7% or less hinges largely on
one’s ability to manage post-meal glucose levels.
Long-Term Problems
(cont'd.)
Research conducted years ago
showed that the first signs of kidney disease begin
to appear much earlier in people with postprandial
hyperglycemia. The higher the postprandial glucose,
the more rapid the onset of proteinuria.
52 People with type 1
diabetes, similar BP between groups
Post-prandial
glucose |
Range |
Time to
onset of proteinuria |
Persistent
<200 |
110-198 |
23 yrs |
Intermittent
>200 |
118-228 |
19 yrs |
Persistent >
200 |
201 + |
14 yrs |
|
People with type 2 diabetes,
starting on oral medications
For
those who use oral medications to manage their
glucose levels, those who use medications
specifically designed to control post-meal glucose
maintained healthy cognitive function, while those
who used meds designed to control pre-meal glucose
levels saw deterioration in cognitive function.
|
Meds to limit post-meal rise |
Meds to
control pre-meal BGs |
HbA1c reduction |
Identical |
Identical |
Fasting BG |
Identical |
Identical |
Cognitive Function |
Unchanged |
Declined |
|