Journal Club

Hemophilia and Factor

 

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Causes:
Let’s look at some of the causes of hemophilia.

In some cases bleeding disorders are caused by rare inherited disorders. In other cases they are developed during certain illnesses such as severe liver disease, or treatments such as use of anticoagulant drugs or prolonged use of antibiotics. In fact, there are many causes of bleeding disorders, including the following:

• Immune system-related diseases, such as medication-related allergic reactions or reactions to infection
• von Willebrand's disease , an inherited blood disorder that affects less than 2% of the population
• Various cancers, such as leukemia
• Antibodies
• Liver disease
• Bone marrow problems
• Medicines, such as aspirin, heparin, warfarin, and drugs used to break up blood clots
• Disseminated intravascular coagulation, linked with certain types of cancers, infections and child
bearing, all characterized by abnormal blood clotting
• Eclampsia
• Organ transplant rejection

 

Recent Progress:

There are numerous advances that have made life with hemophilia more normal and enjoyable. These include:

• Medically supervised home-infusion therapy
• New clotting factor products
• Synthetic clotting products (free from blood products)
• Prophylactic treatment
• Improved screening methods
• New drugs such as desmopressin acetate (DDAVP) used to treat mild-to-moderate hemophilia A and von Willebrand’s disease)
• Improved surgical options
• Newly Advanced genetic testing methods

 

Resources:

The National Hemophilia Foundation (NHF)
NHF seeks to enhance the quality of life and promote the health of people with bleeding disorders. With 42 chapters nationwide, NHF engages in a number of activities. It supports clinical research and provides education to professionals, the bleeding disorders community, and the public at large. It also delivers patient and community services, advocates on behalf of the bleeding disorders community, and makes health policy recommendations. Finally, it addresses HIV and related health problems and offers a range of information services and publications through HANDI, its information center. Click here to learn more about NHF.

HANDI
This is an information resource for bleeding disorders professionals and consumers. HANDI produces and distributes a variety of materials. It responds to over 7,000 calls per year asking for information on many subjects, including new issues like genetic engineering, genetic testing options, recently approved treatments, and blood safety technologies. HANDI's information specialists handle telephone requests from 9AM to 6PM Eastern Time, Monday through Friday. Click here to learn more about HANDI and its publications.

Local Chapters
The 37 local chapters of NHF provide materials, information, advocacy, help in accessing appropriate health services, links to emotional support, financial assistance, and other services.

Hemophilia Treatment Centers (HTCs)
Hemophilia Treatment Centers offer comprehensive medical and psychosocial resources for persons with bleeding disorders. They also offer risk reduction information and counseling, HIV education, resource materials, and referrals to other agencies. To find an HTC nearest you, contact NHF's HANDI.

Resource information provided by the Bleeding Disorder Info Center at http://www.hemophilia.org/bdi/bdi_resources.htm.

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